Benchtop SS-OCT – layout and performance evaluation
Abstract
Abstract1— Optical coherence tomography (OCT) is a non-invasive biomedical imaging technique that provides high speed and high resolution three dimensional and cross sectional images of biological samples, in vivo and in situ. OCT applications targeting small animals is believed to bring developments in medical techniques, instruments, diagnosis and therapies for a number of human diseases as always have been the case of animal experimentation.
With the swept source OCT (SS-OCT) system presented in this work, we were able to achieve performance parameters that meet the requirements to image the retina of small animals. Performance characteristics include 105 dB for system sensitivity, a roll-off below 1 dB/mm over 3 mm depth and an axial resolution of 8 μm. We describe the layout and acquisition/processing solutions towards fast imaging of in vivo samples.
Keywords
Full Text:
PDFReferences
Tomlins P H and Wang R K (2005) Theory, developments and applications of optical coherence tomography. Journal of Physics: Appl. Phys. 38, pp. 2519-2535 DOI 10.1088/0022-3727/38/15/002
Targowski, P Wojtkowski M et al (2004) Complex spectral OCT in human eye imaging in vivo. Optics Communications 229 pp. 79-84.
Marschall S, Sander B et al (2011) Optical coherence tomography – current technology and applications in clinical and biomedical research. Anal Bioanal Chem 400 pp. 2699-2720 DOI 10.1007/s00216-011-5008-1
Huang D, Swanson C et al (1991) Optical Coherence Tomography. Science, 254(5035) pp. 1178-1181
Silva, S., Domingues, J., Agnelo J, Morgado A, Bernardes R (2014), Development of an Optical Coherence Tomograph for Small Animal Retinal Imaging, IFMBE Proceedings Volume 41, , pp 419-422. DOI: 10.1007/978-3-319-00846-2_104
W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second.,” Opt. Express, vol. 18, no. 14, pp. 14685–14704, 2010.
M. D Bayleyegn, H. Makhlouf et al (2012) Ultrahigh Resolution spectral-domain optical coherence tomography at 1.3 μm using a broadband superluminescent diode light source, Opt Commun., vol 285, nº 24, pp 5564-5569
DOI: http://dx.doi.org/10.34629/ipl.isel.i-ETC.22
Refbacks
- There are currently no refbacks.
Copyright (c) 2017 Jose Paulo Domingues
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.